Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy

Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy

Oxidative stress and impaired mitophagy are the hallmarks of cardiomyocyte senescence. Specifically, a decrease in mitophagic flux leads to the accumulation of damaged mitochondria and the development of senescence through increased ROS and other mediators. In this study, we describe the preventive...

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Bibliographic Details
Main Authors: Eleonora Foglio, Erica D’Avorio, Laura Vitiello, Laura Masuelli, Roberto Bei, Francesca Pacifici, David Della-Morte, Simone Mirabilii, Maria Rosaria Ricciardi, Agostino Tafuri, Enrico Garaci, Matteo Antonio Russo, Marco Tafani, Federica Limana
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
cardiac senescence
reactive oxygen species
polyphenols
mitophagy
SIRT3
SIRT4
Online Access:https://www.mdpi.com/2073-4409/12/22/2605

Internet

https://www.mdpi.com/2073-4409/12/22/2605

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