Investigation of 11p15.5 Methylation Defects Associated with Beckwith-Wiedemann Spectrum and Embryonic Tumor Risk in Lateralized Overgrowth Patients

Investigation of 11p15.5 Methylation Defects Associated with Beckwith-Wiedemann Spectrum and Embryonic Tumor Risk in Lateralized Overgrowth Patients

The Beckwith–Wiedemann spectrum (BWSp) ranges from isolated lateralized overgrowth (ILO) to classic phenotypes. In this broad clinical spectrum, an epigenetic alteration on chromosome 11p15.5 can be detected. The risk for embryonal tumors is high, especially in patients with lateralized overgrowth (...

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Bibliographic Details
Main Authors: Beyhan Tüysüz, Serdar Bozlak, Dilek Uludağ Alkaya, Süheyla Ocak, Büşra Kasap, Evrim Sunamak Çifçi, Ali Seker, Ilhan Avni Bayhan, Hilmi Apak
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
11p15 methylation defects
Beckwith–Wiedemann spectrum
lateralized overgrowth
Wilms tumor
embryonal tumors
Online Access:https://www.mdpi.com/2072-6694/15/6/1872

Internet

https://www.mdpi.com/2072-6694/15/6/1872

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