Controllable DNA hybridization by host–guest complexation-mediated ligand invasion

Direct dissociation of nucleic acid duplex structures without heating or specific binding proteins is challenging. Here the authors use the cucurbit[7]uril-based host–guest system to construct a ligand-invasion pathway for controllable DNA hybridisation.

Bibliographic Details
Main Authors: Lin Xiao, Liang-Liang Wang, Chao-Qun Wu, Han Li, Qiu-Long Zhang, Yang Wang, Liang Xu
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33738-3