Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

Abstract Background Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addres...

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Bibliographic Details
Main Authors: Vyara Todorova, Mia Fee Stauffacher, Luca Ravotto, Sarah Nötzli, Duygu Karademir, Lynn J. A. Ebner, Cornelia Imsand, Luca Merolla, Stefanie M. Hauck, Marijana Samardzija, Aiman S. Saab, L. Felipe Barros, Bruno Weber, Christian Grimm
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Neurodegeneration
Subjects:
Hypoxia
Rod photoreceptor
Energy metabolism
Retinal degeneration
Aging
Retinal proteomics
Online Access:https://doi.org/10.1186/s13024-023-00602-x

Internet

https://doi.org/10.1186/s13024-023-00602-x

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