Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9

Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9

Mutations in Colony-stimulating factor 1 receptor (CSF1R) lead to CSF1R-related leukoencephalopathy, also known as Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rapidly progressing neurodegenerative disease with severe cognitive and motor impairment. In this stud...

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Bibliographic Details
Main Authors: Anne S. Schmitz, Milena Korneck, Janani Raju, Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Markus Mezger, Ludger Schöls, Stefan Hauser, Stefanie N. Hayer
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506123000521

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http://www.sciencedirect.com/science/article/pii/S1873506123000521

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