An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

A recently reported parallel preclinical study between a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine and an inactivated SARS-CoV-2 vaccine adjuvanted with alum showed pulmonary immunopathology typical of eosinophil accumulation in a mouse pneumonia model for the latter,...

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Bibliographic Details
Main Authors: Han Cao, Shengran Yang, Yunfei Wang, Ning Luan, Xingxiao Yin, Kangyang Lin, Cunbao Liu
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Vaccines
Subjects:
SARS-CoV-2 subunit vaccine
Th1/Th2 orientation
alum adjuvant
nucleic acid adjuvant
prime-boost
homogenous boost immunization
Online Access:https://www.mdpi.com/2076-393X/9/11/1261

Internet

https://www.mdpi.com/2076-393X/9/11/1261

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