Evaluation of hyperpolarized [1-¹³C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time.
Ionizing radiation (IR) cytotoxicity is primarily mediated through reactive oxygen species (ROS). Since tumor cells neutralize ROS by utilizing reducing equivalents, we hypothesized that measurements of reducing potential using real-time hyperpolarized (HP) magnetic resonance spectroscopy (MRS) and...
Principais autores: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | English |
Publicado em: |
Public Library of Science (PLoS)
2014-01-01
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coleção: | PLoS ONE |
Acesso em linha: | http://europepmc.org/articles/PMC3903593?pdf=render |