Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Generating the whole organ in conjunction with the thymus is a significant milestone for organ transplantation because the thymus is the central organ to educate immune cells. Using lineage-tracing m...

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Bibliographic Details
Main Authors: Akihiro Miura, Hemanta Sarmah, Junichi Tanaka, Youngmin Hwang, Anri Sawada, Yuko Shimamura, Takehiro Otoshi, Yuri Kondo, Yinshan Fang, Dai Shimizu, Zurab Ninish, Jake Le Suer, Nicole C Dubois, Jennifer Davis, Shinichi Toyooka, Jun Wu, Jianwen Que, Finn J Hawkins, Chyuan-Sheng Lin, Munemasa Mori
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
lung generation
conditional blastocyst complementation
lung mesenchyme precursors
mesendoderm
whole organ generation
thymus generation
Online Access:https://elifesciences.org/articles/86105

Internet

https://elifesciences.org/articles/86105

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