Therapeutic Drug Monitoring of Tacrolimus Based on Volumetric Absorptive Microsampling Technique (VAMS) in Renal Transplant Pediatric Recipients—LC-MS/MS Method Development, Hematocrit Effect Evaluation, and Clinical Application

Therapeutic Drug Monitoring of Tacrolimus Based on Volumetric Absorptive Microsampling Technique (VAMS) in Renal Transplant Pediatric Recipients—LC-MS/MS Method Development, Hematocrit Effect Evaluation, and Clinical Application

Tacrolimus (TAC) is post-transplant pharmacotherapy’s most widely used immunosuppressant. In routine clinical practice, frequent uncomfortable venipuncture is necessary for whole-blood (WB) collection to check trough TAC levels. Volumetric absorptive microsampling (VAMS) is an alternative strategy t...

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Bibliographic Details
Main Authors: Arkadiusz Kocur, Dorota Marszałek, Jacek Rubik, Agnieszka Czajkowska, Tomasz Pawiński
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
VAMS
tacrolimus
hematocrit effect
whole blood
kidney transplantation
pediatric population
Online Access:https://www.mdpi.com/1999-4923/15/1/299

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https://www.mdpi.com/1999-4923/15/1/299

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