Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic <i>Escherichia coli</i>-Induced Blood–Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis

Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic <i>Escherichia coli</i>-Induced Blood–Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis

Despite the availability of antibiotics over the last several decades, excessive antibiotic treatments for bacterial sepsis and meningitis (BSM) in children may result in several adverse outcomes. Hematogenous pathogens may directly induce permeability increases in human brain microvascular endothel...

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Bibliographic Details
Main Authors: Zelong Gong, Xuefeng Gao, Yubin Li, Jinhu Zou, Jingxian Lun, Jie Chen, Chengxing Zhou, Xiaolong He, Hong Cao
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
bacterial sepsis and meningitis
alpha7 nicotinic acetylcholine receptor
blood–brain barriers
cytokine-inducible SH2-containing protein
Online Access:https://www.mdpi.com/2227-9059/10/10/2358

Internet

https://www.mdpi.com/2227-9059/10/10/2358

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