Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Abstract Background The type 1 interferon (IFN) response is part of the innate immune response and best known for its role in viral and bacterial infection. However, this pathway is also induced in sterile inflammation such as that which occurs in a number of neurodegenerative diseases, including ne...

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Bibliographic Details
Main Authors: Ayelet Vardi, Shifra Ben-Dor, Soo Min Cho, Ulrich Kalinke, Julia Spanier, Anthony H. Futerman
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Gaucher disease
Pathogen recognition receptors
Type 1 interferon
Neurodegenerative diseases
Lipid metabolism
Lysosomal storage diseases
Online Access:http://link.springer.com/article/10.1186/s12974-020-01934-x

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http://link.springer.com/article/10.1186/s12974-020-01934-x

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