Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

The type VI secretion system (T6SS) secretes antibacterial effectors into target competitors. Salmonella spp. encode five phylogenetically distinct T6SSs. Here, we characterize the function of the SPI-22 T6SS of Salmonella bongori showing that it has antibacterial activity and identify a group of an...

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Bibliographic Details
Main Authors: Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache, Gianlucca Gonçalves Nicastro, Liam Mead, Edgar Enrique Llontop, Gustavo Chagas-Santos, Chuck Shaker Farah, Robson Francisco de Souza, Rodrigo da Silva Galhardo, Andrew L Lovering, Ethel Bayer-Santos
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
Salmonella
T6SS
effector
toxin
VRR-Nuc
nuclease
Online Access:https://elifesciences.org/articles/82437

Internet

https://elifesciences.org/articles/82437

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