Enhancing prime editor flexibility with coiled-coil heterodimers
Abstract Background Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of prime editors (PEs) hampers their delivery in vivo via adeno-associated v...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
BMC
2024-04-01
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| Colección: | Genome Biology |
| Acceso en línea: | https://doi.org/10.1186/s13059-024-03257-z |