Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients

Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients

Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-19 severity in mild and severe cases of the disease. We verifi...

Full description

Bibliographic Details
Main Authors: Anna Julia Pietrobon, Roberta Andrejew, Ricardo Wesley Alberca Custódio, Luana de Mendonça Oliveira, Juliete Nathali Scholl, Franciane Mouradian Emidio Teixeira, Cyro Alves de Brito, Talita Glaser, Julia Kazmierski, Christine Goffinet, Anna Claudia Turdo, Tatiana Yendo, Valeria Aoki, Fabricio Figueiró, Ana Maria Battastini, Henning Ulrich, Gill Benard, Alberto Jose da Silva Duarte, Maria Notomi Sato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
adenosine
ATP
CD39
CD73
COVID-19
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012027/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012027/full

Similar Items