Generation of mutation-corrected induced pluripotent stem cell lines derived from adrenoleukodystrophy patient by using homology directed repair

Generation of mutation-corrected induced pluripotent stem cell lines derived from adrenoleukodystrophy patient by using homology directed repair

X-linked adrenoleukodystrophy (ALD) caused by the ABCD1 mutation, is the most common inherited peroxisomal disease. Previously, we generated an ALD patient-derived SCHi001-A iPSC model. In this study, we have performed the first genome editing of ALD patient-derived SCHi001-A iPSCs using homology-di...

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Bibliographic Details
Main Authors: Eul Sik Jung, Ji Hun Kim, Mi-Yoon Chang, Wonjun Hong, Zhejiu Quan, Seung Hyun Kim, Seungkwon You, Dae-Sung Kim, Jiho Jang, Sang-Hun Lee, Hyongbum Henry Kim, Hoon Chul Kang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Stem Cell Research
Subjects:
X-linked adrenoleukodystrophy
Induced pluripotent stem cell
Genome editing
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122000137

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http://www.sciencedirect.com/science/article/pii/S1873506122000137

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