Targeting tumor cells with pyrazolo[3,4-d]pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target-based mechanisms

Targeting tumor cells with pyrazolo[3,4-d]pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target-based mechanisms

Pyrazolo[3,4-d]pyrimidine had been attracted awesome interest due to its pharmacological potential especially as an anticancer. Several mechanisms of action were accounted for the anticancer potential of this privileged scaffold. Previous researches explained its role in binding with many receptors...

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Bibliographic Details
Main Authors: Mohamed A. Abdelgawad, Nadia A.A. Elkanzi, A.A. Nayl, Arafa Musa, Nasser Hadal Alotaibi, W.A.A. Arafa, Sobhi M. Gomha, Rania B. Bakr
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Arabian Journal of Chemistry
Subjects:
Pyrazolopyrimidines
Anticancer agents
Kinases
EGFR
SAR
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222000971

Internet

http://www.sciencedirect.com/science/article/pii/S1878535222000971

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