HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as cholesterol-mediated effects. In fact, data from s...

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Bibliographic Details
Main Authors: Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Journal of Lipid Research
Subjects:
adenosine 5′-triphosphate binding cassette transporter
cytochrome P450 enzyme
high density lipoprotein
cholesterol efflux
cholesterol metabolism
oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752043500X

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http://www.sciencedirect.com/science/article/pii/S002222752043500X

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