Doppelgänger spotting in biomedical gene expression data

Summary: Doppelgänger effects (DEs) occur when samples exhibit chance similarities such that, when split across training and validation sets, inflates the trained machine learning (ML) model performance. This inflationary effect causes misleading confidence on the deployability of the model. Thus, s...

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Bibliographic Details
Main Authors: Li Rong Wang, Xin Yun Choy, Wilson Wen Bin Goh
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222010604