Phospholipid Encapsulation of an Anti-Fibrotic Endopeptide to Enhance Cellular Uptake and Myocardial Retention

Phospholipid Encapsulation of an Anti-Fibrotic Endopeptide to Enhance Cellular Uptake and Myocardial Retention

Background: Cardioprotective effects of <i>N</i>-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use. Method: To prolong its bioavailability, Ac-SDKP...

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Bibliographic Details
Main Authors: Swati D. Sonkawade, Shirley Xu, Minhyung Kim, Sarmila Nepali, Victoire-Grace Karambizi, Sandra Sexton, Steven G. Turowski, Kunpeng Li, Joseph A. Spernyak, Jonathan F. Lovell, Anthony George, Sujit Suwal, Umesh C. Sharma, Saraswati Pokharel
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
liposome
RAW 264.7 macrophages
C57BL/6j
cardiac fibroblasts
myocardial infarction
bioavailability
Online Access:https://www.mdpi.com/2073-4409/12/12/1589

Internet

https://www.mdpi.com/2073-4409/12/12/1589

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