Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis

Background: Ferroptosis is a new form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides and membrane damages. Recent studies have identified an important role for cancer cell ferroptosis in antitumor therapy. On the other hand, polyphyllin I (PPI) has been r...

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Bibliographic Details
Main Authors: Fang Zheng, Yeshu Wang, Qunfang Zhang, Qiuyuan Chen, Chun-Ling Liang, Huazhen Liu, Feifei Qiu, Yuchao Chen, Haiding Huang, Weihui Lu, Zhenhua Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
gastric cancer
NRF2
polyphyllin I
anticancer drug
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1145407/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1145407/full

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