In Vitro Stimulation of Multidrug Resistance-Associated Protein 2 Function Is Not Reproduced In Vivo in Rats

In Vitro Stimulation of Multidrug Resistance-Associated Protein 2 Function Is Not Reproduced In Vivo in Rats

Previously we reported that coproporphyrin-I (CP-I) is an optimal probe substrate for multidrug resistance-associated protein 2 (MRP2), and stimulation of MRP2-mediated transport is probe substrate-dependent. In the present investigation, we assessed if the in vitro stimulation is physiologically re...

Full description

Bibliographic Details
Main Authors: Ravindranath Reddy Gilibili, Vishwanath Kurawattimath, Bokka Venkata Murali, Yurong Lai, T. Thanga Mariappan, Hong Shen, Sagnik Chatterjee
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
ABCC2
MRP2
in vitro stimulation
drug transporter
coproporphyrin
Online Access:http://www.mdpi.com/1999-4923/10/3/125

Internet

http://www.mdpi.com/1999-4923/10/3/125

Similar Items