Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer’s Disease

Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer’s Disease

The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interroga...

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Bibliographic Details
Main Authors: Mercedes Lachen-Montes, Andrea González-Morales, Maialen Palomino, Karina Ausin, Marta Gómez-Ochoa, María Victoria Zelaya, Isidro Ferrer, Alberto Pérez-Mediavilla, Joaquín Fernández-Irigoyen, Enrique Santamaría
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
olfactory bulb
network biology
proteomics
transcriptomics
Tg2576 mice
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00141/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00141/full

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