A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

Abstract p53-mediated cell cycle arrest during DNA damage is dependent on the induction of p21 protein, encoded by the CDKN1A gene. p21 inhibits cyclin-dependent kinases required for cell cycle progression to guarantee accurate repair of DNA lesions. Hence, fine-tuning of p21 levels is crucial to pr...

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Bibliographic Details
Main Authors: Bella M. Ben-Oz, Feras E. Machour, Marian Nicola, Amir Argoetti, Galia Polyak, Rawad Hanna, Oded Kleifeld, Yael Mandel-Gutfreund, Nabieh Ayoub
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43495-6

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https://doi.org/10.1038/s41467-023-43495-6

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