Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study

Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study

Abstract Background The role of the complement system in the pathogenesis of systemic sclerosis (SSc) is controversial. This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion injury in SSc. Methods This is a prospective observational cross-sectiona...

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Bibliographic Details
Main Authors: Michael Osthoff, Veronika K. Jaeger, Ingmar A. F. M. Heijnen, Marten Trendelenburg, Suzana Jordan, Oliver Distler, Ulrich A. Walker
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Arthritis Research & Therapy
Subjects:
Mannose-binding lectin
Ficolin-2
Systemic sclerosis
Complement system
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s13075-019-1859-1

Internet

http://link.springer.com/article/10.1186/s13075-019-1859-1

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