Anti-inflammation-based treatment of atherosclerosis using Gliclazide-loaded biomimetic nanoghosts

Abstract In the study, a biomimetic platform for anti-inflammatory-based treatment of atherosclerotic plaque was developed. Gliclazide (GL) as an anti-inflammasome agent was encapsulated in PLGA nanoparticles (NP), which were coated by monocyte membrane using an extrusion procedure. The size and zet...

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Bibliographic Details
Main Authors: Zahra Karami, Jalil Mehrzad, Mohammad Akrami, Saman Hosseinkhani
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41136-y