Suppressing STAT5 signaling affects osteosarcoma growth and stemness

Suppressing STAT5 signaling affects osteosarcoma growth and stemness

Abstract Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. Cells treated with pimozide, a STAT5 inhibitor suppressed proliferation and colony formation and i...

Full description

Bibliographic Details
Main Authors: Dharmalingam Subramaniam, Pablo Angulo, Sivapriya Ponnurangam, Prasad Dandawate, Prabhu Ramamoorthy, Pugazhendhi Srinivasan, Tomoo Iwakuma, Scott J. Weir, Katherine Chastain, Shrikant Anant
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-2335-1

Internet

https://doi.org/10.1038/s41419-020-2335-1

Similar Items