Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors

Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors

A series of pyrazolyl-s-triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds 3h, 3i, and 3j showed promising cytotoxic activity agai...

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Bibliographic Details
Main Authors: Ihab Shawish, Mohamed S. Nafie, Assem Barakat, Ali Aldalbahi, Hessa H. Al-Rasheed, M. Ali, Walhan Alshaer, Mazhar Al Zoubi, Samha Al Ayoubi, Beatriz G. De la Torre, Fernando Albericio, Ayman El-Faham
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Chemistry
Subjects:
pyrazolyl-s-triazine
indole
anticancer profile
EGFR/CDK-2
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1078163/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1078163/full

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