Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies

Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies

Abstract Background The 16S rRNA gene is used extensively in bacterial phylogenetics, in species delineation, and now widely in microbiome studies. However, the gene suffers from intragenomic heterogeneity, and reports of recombination and an unreliable phylogenetic signal are accumulating. Here, we...

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Bibliographic Details
Main Authors: Hayley B. Hassler, Brett Probert, Carson Moore, Elizabeth Lawson, Richard W. Jackson, Brook T. Russell, Vincent P. Richards
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Microbiome
Subjects:
16S rRNA gene
Comparative phylogenomics
Microbiome
Diversity metrics
Entropy masking
Recombination
Online Access:https://doi.org/10.1186/s40168-022-01295-y

Internet

https://doi.org/10.1186/s40168-022-01295-y

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