Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 protein biomarkers on 14 TMAs with prospectively coll...

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Bibliographic Details
Main Authors: Konrad H Stopsack, Svitlana Tyekucheva, Molin Wang, Travis A Gerke, J Bailey Vaselkiv, Kathryn L Penney, Philip W Kantoff, Stephen P Finn, Michelangelo Fiorentino, Massimo Loda, Tamara L Lotan, Giovanni Parmigiani, Lorelei A Mucci
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
tissue microarray
batch effect
measurement error
batchtma
R package
Online Access:https://elifesciences.org/articles/71265

Internet

https://elifesciences.org/articles/71265

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