A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days

A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days

Abstract Background While DNA and RNA methods are routine to disrupt the expression of specific genes, complete understanding of developmental processes requires also protein methods, because: oocytes and early embryos accumulate proteins and these are not directly affected by DNA and RNA methods. W...

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Bibliographic Details
Main Authors: Steffen Israel, Ellen Casser, Hannes C.A. Drexler, Georg Fuellen, Michele Boiani
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Genomics
Subjects:
Proteome
TEAD4
Oocyte
Preimplantation embryo
TRIM21
Mouse
Online Access:http://link.springer.com/article/10.1186/s12864-019-6106-2

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http://link.springer.com/article/10.1186/s12864-019-6106-2

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