Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Abstract Introduction Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating IC might be of prognostic value. Methods A C1q-binding-eluting techn...

Full description

Bibliographic Details
Main Authors: Azita Sohrabian, Ioannis Parodis, Nellie Carlströmer-Berthén, Martina Frodlund, Andreas Jönsen, Agneta Zickert, Christopher Sjöwall, Anders A. Bengtsson, Iva Gunnarsson, Johan Rönnelid
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
Belimumab
Anti-nuclear autoantibodies
Anti-double-stranded DNA
Immune complexes
Therapy response
Online Access:https://doi.org/10.1186/s13075-019-2056-y

Internet

https://doi.org/10.1186/s13075-019-2056-y

Similar Items