In vitro and in silico evaluation of the antimicrobial and antioxidant activities of spiropyrazoline oxindole congeners

In vitro and in silico evaluation of the antimicrobial and antioxidant activities of spiropyrazoline oxindole congeners

The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one congeners were assessed for their in vitro bioactivities, and in-silico studies were conducted to support the experiment...

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Bibliographic Details
Main Authors: Mohammed Chalkha, Khalid Chebbac, Hassan Nour, Asmae Nakkabi, Abdelfattah El Moussaoui, Burak Tüzün, Mohammed Bourhia, Samir Chtita, Mohamed Bakhouch, Hamid Laaroussi, Sarkar M.A. Kawsar, Taibi Ben Hadda, Ghali Al Houari, Maria Augustyniak, Mourad A.M. Aboul-Soud, Mohamed El Yazidi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Arabian Journal of Chemistry
Subjects:
Spiropyrazoline oxindoles
Antimicrobial property
Antioxidant potency
Molecular docking
MD simulations
POM analyses
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223009279

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http://www.sciencedirect.com/science/article/pii/S1878535223009279

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