Molecular mechanism underlying the selective attack of trehalose lipids on cancer cells as revealed by coarse-grained molecular dynamics simulations

Molecular mechanism underlying the selective attack of trehalose lipids on cancer cells as revealed by coarse-grained molecular dynamics simulations

The present study indicated that the mixed lipid bilayer of dimyristoylphosphatidylcholine (DMPC) and trehalosemonomyristate (TreC14) interacted strongly with the plasma membrane of cancer cells, and not that of normal cells, when the composition of TreC14 was 70%, as revealed by coarse-grained mole...

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Detaylı Bibliyografya
Asıl Yazarlar: Ryosuke Hirano, Takashi Kagamiya, Yoko Matsumoto, Tadaomi Furuta, Minoru Sakurai
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2021-03-01
Seri Bilgileri:Biochemistry and Biophysics Reports
Konular:
Cancer therapy
Trehalosemonomyristate
Phosphatidylinositol
Phosphatidylserine
Membrane curvature
Membrane fusion
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2405580821000078

Internet

http://www.sciencedirect.com/science/article/pii/S2405580821000078

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