Determination of Lysergic Acid Diethylamide and 2-Oxo-3-Hydroxy-LSD in Blood: Validation and Comparison of Two Liquid Chromatography–Tandem Mass Spectrometry Methods

Lysergic acid diethylamide (LSD) is a powerful hallucinogen. Its detection is limited by its low dosage; moreover, LSD is rapidly metabolized into 2-oxo-3-hydroxy-LSD (O-H-LSD). In this study we validated two methods for determination of LSD and O-H-LSD in blood. Method #1 consisted in the upgrade o...

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Bibliographic Details
Main Authors: Alexandra Dimitrova, Maria Grazia Di Milia, Regina Rensi, Simone Grassi, Barbara Gualco, Fabio Vaiano
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Separations
Subjects:
Online Access:https://www.mdpi.com/2297-8739/10/9/502