An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

Summary: Elevated serine peptidase inhibitor, Kazal type 1 (SPINK1) levels in ∼10%–25% of prostate cancer (PCa) patients associate with aggressive phenotype, for which there are limited treatment choices and dismal clinical outcomes. Using an integrative proteomics approach involving label-free phos...

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Bibliographic Details
Main Authors: Nishat Manzar, Umar Khalid Khan, Ayush Goel, Shannon Carskadon, Nilesh Gupta, Nallasivam Palanisamy, Bushra Ateeq
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Cancer
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000154

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http://www.sciencedirect.com/science/article/pii/S2589004224000154

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