Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment

Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment

Abstract The toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP), a functional analysis of the effect...

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Bibliographic Details
Main Authors: Fatima Abbas, Laila Ananda Blömer, Hugo Millet, Jérôme Montnach, Michel De Waard, Marco Canepari
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
AaH-II toxin
Voltage-gated sodium channels
Axon initial segment
Action potential
Neocortical layer-5 pyramidal neuron
Calcium
Online Access:https://doi.org/10.1038/s41598-024-55315-y

Internet

https://doi.org/10.1038/s41598-024-55315-y

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