Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease

Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease

Sickle cell disease (SCD) is a monogenic disorder that affects 100,000 African-Americans and millions of people worldwide. Intra-erythrocytic polymerization of sickle hemoglobin (HbS) promotes erythrocyte sickling, impaired rheology, ischemia and hemolysis, leading to the development of progressive...

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Bibliographic Details
Main Authors: Tomasz W. Kaminski, Omika Katoch, Ziming Li, Corrine B. Hanway, Rikesh K. Dubey, Adekunle Alagbe, Tomasz Brzoska, Hong Zhang, Prithu Sundd, Gregory J. Kato, Enrico M. Novelli, Tirthadipa Pradhan-Sundd
Format: Article
Language:English
Published: Ferrata Storti Foundation 2023-11-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11337

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https://haematologica.org/article/view/11337

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