Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

The Notch signaling pathway plays a fundamental role for the terminal differentiation of multiple cell types, including B and T lymphocytes. The Notch receptors are transmembrane proteins that, upon ligand engagement, undergo multiple processing steps that ultimately release their intracytoplasmic p...

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Bibliographic Details
Main Authors: Federico Pozzo, Tamara Bittolo, Erika Tissino, Antonella Zucchetto, Riccardo Bomben, Laura Polcik, Svenja Dannewitz Prosseda, Tanja Nicole Hartmann, Valter Gattei
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
NOTCH1
FBXW7
chronic lymphocytic leukemia
gene mutations
Online Access:https://www.mdpi.com/2072-6694/14/12/2997

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https://www.mdpi.com/2072-6694/14/12/2997

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