Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Abstract Background High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in ovarian cancer (OV) remain markedly unknown. Methods The expression of...

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Bibliographic Details
Main Authors: Hongjuan Chai, Chunpeng Pan, Mingyang Zhang, Haizhong Huo, Haiyan Shan, Jugang Wu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Cancer
Subjects:
SETD1A
Notch1
Gene regulation
Ovarian cancer
Tumorigenesis
Online Access:https://doi.org/10.1186/s12885-023-10573-3

Internet

https://doi.org/10.1186/s12885-023-10573-3

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