The discovery of some promising putative binders of KRAS G12D receptor using computer-aided drug discovery approach

The discovery of some promising putative binders of KRAS G12D receptor using computer-aided drug discovery approach

A prospective target for the therapy of solid tumors is KRAS G12D, the most prevalent oncogenic KRAS mutation. However, despite decades of research that focused on the identification of druggable compounds against this highly challenging therapeutic cancer target, no drug has been clinically approve...

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Bibliographic Details
Main Authors: Abdul-Quddus Kehinde Oyedele, Nurudeen Abiodun Owolabi, Tope Tunji Odunitan, Abosede Ajibare Christiana, Rukayat Olajumoke Jimoh, Waliu Olatunji Abdul Azeez, Maryam Bello-Hassan Titilayo, Abiola Sarah Soares, Adedayo Toluwani Adekola, Teslim Oluwaseyi Abdulkareem, Samson Olabode Oyelekan, Mojeed Ayoola Ashiru, Ibrahim Olajide Gbadebo, Habeebah Eyinade Olajumoke, Ibrahim Damilare Boyenle, Abdeen Tunde Ogunlana
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Cancer therapeutics
Computer-aided drug design
KRAS G12D
Molecular docking
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914823000126

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http://www.sciencedirect.com/science/article/pii/S2352914823000126

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