TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer

TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer

Abstract Background Upregulation of the PD-L1 (CD274) immune checkpoint ligand on the tumor surface facilitates tumor immune escape and limits the application of immunotherapy in various cancers, including breast cancer. However, the mechanisms underlying high PD-L1 levels in cancers are still poorl...

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Bibliographic Details
Main Authors: Xinrui Dong, Huijuan Dai, Yanping Lin, Xiaonan Sheng, Ye Li, Yaohui Wang, Xueli Zhang, Shuheng Jiang, Wenjin Yin, Jinsong Lu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
TIMELESS
PD-L1
CD8+ T lymphocytes
Breast cancer
Online Access:https://doi.org/10.1186/s12967-023-04257-6

Internet

https://doi.org/10.1186/s12967-023-04257-6

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