Neuroprotective effects of DAHP and Triptolide in Focal Cerebral Ischemia via Apoptosis Inhibition and PI3K/Akt/mTOR pathway Activation

Neuroprotective effects of DAHP and Triptolide in Focal Cerebral Ischemia via Apoptosis Inhibition and PI3K/Akt/mTOR pathway Activation

Triptolide (TP), one of the major active components of the traditional Chinese herb Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of tetrahydrobiopterin (BH4) synthesis, have been reported to have potent anti-inflammatory and immunosuppressive properties. Ho...

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Bibliographic Details
Main Authors: Weiyun eLi, Yang eYang, Zhiying eHu, Shucai eLing, Marong eFang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Neuroanatomy
Subjects:
Neuroprotection
anti-apoptosis
cerebral ischemia
PI3K/AKT/mTOR
Triptolide
DAHP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00048/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00048/full

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