Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents

Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents

Abstract Herein, we reported the synthesis of nineteen novel 1,2,4-triazole derivatives including 1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl) propan-1-ones (7a-e), 1-(1,3-diphenylpropan-2-yl)-1H-1,2,4-triazole (8a-c) and 1,4-diphenyl-2-(1H-1,2,4-triazol-1-yl) butane-1,4-diones (10a-k). The structures of...

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Bibliographic Details
Main Authors: Leila Emami, Sara Sadeghian, Ayyub Mojaddami, Soghra khabnadideh, Amirhossein Sakhteman, Hossein Sadeghpour, Zeinab Faghih, Masood Fereidoonnezhad, Zahra Rezaei
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Chemistry
Subjects:
1,2,4-Triazole
Anticancer
MTT assay
Molecular docking
ADME
Online Access:https://doi.org/10.1186/s13065-022-00887-x

Internet

https://doi.org/10.1186/s13065-022-00887-x

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