Role of Sox9 in BPD and its effects on the Wnt/β-catenin pathway and AEC-II differentiation

Abstract The excessive activation of the Wnt/β-catenin signaling pathway is an important regulatory mechanism that underlies the excessive proliferation and impaired differentiation of type 2 alveolar epithelial cells (AEC-II) in bronchopulmonary dysplasia (BPD). Sox9 has been shown to be an importa...

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Bibliographic Details
Main Authors: Di Wu, Dongqin Bai, Miao Yang, Bo Wu, Wei Xu
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01795-2