LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway

LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway

Because adventitial fibroblasts play an important role in the repair of blood vessels, we assessed whether elevation in LDL concentrations would affect fibroblast function and whether this depended on activation of intracellular signaling pathways. We show here that in primary human fibroblasts, LDL...

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Bibliographic Details
Main Authors: Iveta Dobreva, Gérard Waeber, Vincent Mooser, Richard W. James, Christian Widmann
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Journal of Lipid Research
Subjects:
remodeling
cell spreading
lamellipodia
p38 mitogen-activated protein kinase
low density lipoprotein
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031957X

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http://www.sciencedirect.com/science/article/pii/S002222752031957X

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