Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell response and can be therapeutically targeted t...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30087-z |
| _version_ | 1818007197770055680 |
|---|---|
| author | Yoav Charpak-Amikam Tom Lapidus Batya Isaacson Alexandra Duev-Cohen Tal Levinson Adi Elbaz Francesca Levi-Schaffer Nir Osherov Gilad Bachrach Lois L. Hoyer Maya Korem Ronen Ben-Ami Ofer Mandelboim |
| author_facet | Yoav Charpak-Amikam Tom Lapidus Batya Isaacson Alexandra Duev-Cohen Tal Levinson Adi Elbaz Francesca Levi-Schaffer Nir Osherov Gilad Bachrach Lois L. Hoyer Maya Korem Ronen Ben-Ami Ofer Mandelboim |
| author_sort | Yoav Charpak-Amikam |
| collection | DOAJ |
| description | Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell response and can be therapeutically targeted to restore the anti-Candida immunity. |
| first_indexed | 2024-04-14T05:12:30Z |
| format | Article |
| id | doaj.art-5d4f202e0f1b45458f7c54448f86e0ce |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T05:12:30Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5d4f202e0f1b45458f7c54448f86e0ce2022-12-22T02:10:29ZengNature PortfolioNature Communications2041-17232022-05-0113111310.1038/s41467-022-30087-zCandida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGITYoav Charpak-Amikam0Tom Lapidus1Batya Isaacson2Alexandra Duev-Cohen3Tal Levinson4Adi Elbaz5Francesca Levi-Schaffer6Nir Osherov7Gilad Bachrach8Lois L. Hoyer9Maya Korem10Ronen Ben-Ami11Ofer Mandelboim12The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRICThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRICThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRICThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRICInfectious Diseases Unit, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hebrew University of JerusalemPharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of JerusalemDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Ramat-AvivThe Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental MedicineDepartment of Pathobiology, University of Illinois at Urbana-ChampaignDepartment of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical CenterInfectious Diseases Unit, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv UniversityThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRICNatural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell response and can be therapeutically targeted to restore the anti-Candida immunity.https://doi.org/10.1038/s41467-022-30087-z |
| spellingShingle | Yoav Charpak-Amikam Tom Lapidus Batya Isaacson Alexandra Duev-Cohen Tal Levinson Adi Elbaz Francesca Levi-Schaffer Nir Osherov Gilad Bachrach Lois L. Hoyer Maya Korem Ronen Ben-Ami Ofer Mandelboim Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT Nature Communications |
| title | Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT |
| title_full | Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT |
| title_fullStr | Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT |
| title_full_unstemmed | Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT |
| title_short | Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT |
| title_sort | candida albicans evades nk cell elimination via binding of agglutinin like sequence proteins to the checkpoint receptor tigit |
| url | https://doi.org/10.1038/s41467-022-30087-z |
| work_keys_str_mv | AT yoavcharpakamikam candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT tomlapidus candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT batyaisaacson candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT alexandraduevcohen candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT tallevinson candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT adielbaz candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT francescalevischaffer candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT nirosherov candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT giladbachrach candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT loislhoyer candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT mayakorem candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT ronenbenami candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit AT ofermandelboim candidaalbicansevadesnkcelleliminationviabindingofagglutininlikesequenceproteinstothecheckpointreceptortigit |