Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach.

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach.

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Large-scale genomic alterations play an important role in disease, gene expression, and chromosome evolution. Optical DNA mapping (ODM), commonly categorized into sparsely-labelled ODM and densely-labelled ODM, provides sequence-specific continuous intensity profiles (DNA barcodes) along single DNA...

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Bibliographic Details
Main Authors: Albertas Dvirnas, Callum Stewart, Vilhelm Müller, Santosh Kumar Bikkarolla, Karolin Frykholm, Linus Sandegren, Erik Kristiansson, Fredrik Westerlund, Tobias Ambjörnsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0259670

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https://doi.org/10.1371/journal.pone.0259670

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