Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche

Throughout the process of vascular growth and remodeling, the extracellular matrix (ECM) concurrently undergoes significant changes due to proteolytic activity—regulated by both endothelial and surrounding stromal cells. The role of matrix metalloproteinases has been well-studied in the context of v...

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Bibliographic Details
Main Authors: Simone A. Douglas, Kristina Haase, Roger D. Kamm, Manu O. Platt
Format: Article
Language:English
Published: AIP Publishing LLC 2020-12-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0023342