Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway

Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway

Background: Renal fibrosis, associated with oxidative stress and nitric oxide (NO) deficiency, contributes to the development of chronic kidney disease and renal failure. As major energy source in maintaining renal physiological functions, tubular epithelial cells with decreased fatty acid oxidation...

Full description

Bibliographic Details
Main Authors: Xuechen Li, Zhengbing Zhuge, Lucas Rannier R.A. Carvalho, Valdir A. Braga, Ricardo Barbosa Lucena, Shuijie Li, Tomas A. Schiffer, Huirong Han, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlström
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
Inorganic nitrate
Nitrite
Renal fibrosis
Oxidative stress
AMPK
PGC1α
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000386

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722000386

Similar Items