Sex-Specific Gene-by-Vitamin D Interactions Regulate Susceptibility to Central Nervous System Autoimmunity

Sex-Specific Gene-by-Vitamin D Interactions Regulate Susceptibility to Central Nervous System Autoimmunity

Vitamin D3 (VitD) insufficiency is postulated to represent a major modifiable risk factor for multiple sclerosis (MS). While low VitD levels strongly correlate with higher MS risk in white populations, this is not the case for other ethnic groups, suggesting the existence of a genetic component. Mor...

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Bibliographic Details
Main Authors: Dimitry N. Krementsov, Loredana Asarian, Qian Fang, Mahalia M. McGill, Cory Teuscher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
vitamin D
multiple sclerosis
CD4 T cells
genetic variation
experimental autoimmune encephalomyelitis (EAE)
sex differences
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01622/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01622/full

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